How to Analyze Your 23andMe Raw Data for Detox & Mold Genes
Decode Your Genes
Your genes can provide valuable insights into how well your body detoxifies toxins, processes mold exposure, and handles environmental stressors. Many people use 23andMe to explore their genetic makeup, but the default health reports don’t include everything—especially genes related to detox and mold susceptibility.
If you purchased the Ancestry-only version of 23andMe (or did not opt for the Total Health report), you may not have access to detailed health interpretations. However, you can still download your raw data and analyze it yourself using ChatGPT—no expensive third-party tools required! This guide will show you how.
Locate Your 23andMe Raw Data
Log in to your 23andMe account.
Click your name in the upper right hand corner.
Click “Resources”.
Click “Browse Data” in the “Browse Raw Geneotyping Data” block.
Search for either the gene name (e.g., CYP1A1, GSTM1) or the specific marker (rsID) (which starts with "rs").
Understanding Your Genetic Variants
For each SNP (genetic marker), the first variant listed is the reference (normal) allele, and the second variant is the risk allele. Your genotype will indicate how your body processes detoxification and mold exposure:
If the first variant appears twice in “Your Genotype” (e.g., C/C for a C or T SNP) → Normal function, no genetic impact.
If your result is a combination of the two variants in “Your Genotype” (e.g., A/G for a A or G SNP) → Partial reduction in function, moderate impact.
If the second variant appears twice in “Your Genotype” (e.g., G/G for a A or G SNP) → Stronger impact, potential dysfunction in detox or mold processing.
Key Genes to Look For:
Detoxification Genes (Liver Phase 1 & Phase 2 Detox)
GSTT1 – Glutathione detox pathway (gene deletion reduces detox ability).
GSTM1 – Another critical glutathione detox enzyme.
GSTP1 (rs1695) – Detox efficiency, oxidative stress regulation.
CYP1A1 (rs4646903, rs1048943) – Detox of environmental toxins.
CYP1B1 (rs1056836) – Estrogen metabolism, mold toxin clearance.
CYP2C19 (rs4244285, rs12248560) – Liver detox of medications/toxins.
CYP3A4 (rs2740574) – Detox of drugs, hormones, and toxins.
NQO1 (rs1800566) – Antioxidant function, toxin breakdown.
PON1 (rs662, rs854560) – Pesticide/toxin clearance.
Mold Susceptibility (HLA Genes & Mycotoxin Detox)
HLA-DRB1 (rs9270986, rs3135388, rs6910071) – Mold illness susceptibility. Strongly associated with Chronic Inflammatory Response Syndrome (CIRS). For a comprehensive analysis of HLA-DR/DQ haplotypes related to CIRS, specialized genetic testing beyond standard 23andMe services is recommended.
HLA-DQB1 (rs9275572, rs9275596, rs1046089) – Immune response to mold exposure. Strongly associated with Chronic Inflammatory Response Syndrome (CIRS). For a comprehensive analysis of HLA-DR/DQ haplotypes related to CIRS, specialized genetic testing beyond standard 23andMe services is recommended.
MTHFR (rs1801133, rs1801131) – Methylation & detox efficiency.
HFE (rs1800562, rs1799945, rs855345) – Iron overload & mold toxin clearance.
Take it One Step Further and Use ChatGPT to Analyze Your Genes
Copy Your Genetic Data and Use This Prompt:
I have copied my 23andMe raw data below. Can you analyze my detox and mold-related genes? Please explain:
How these genes affect detoxification or mold sensitivity.
Whether my specific results (A/A, G/G, etc.) indicate a strength, weakness, or neutral effect.
What I can do to support my detox pathways based on my genetics.
Here is my raw genetic data:
[PASTE YOUR GENETIC DATA HERE]
Once ChatGPT processes your genetic data, it will:
Identify detox & mold-related genes (CYP1A1, GSTM1, HLA-DRB1, MTHFR, etc.)
Explain what your genetic variations mean (e.g., slow detox, mold sensitivity)
Offer diet & lifestyle recommendations (e.g., glutathione support, binders, sauna, etc.)
Important Disclosures & Limitations
23andMe Doesn’t Cover All Key Detox Genes
While 23andMe provides a wealth of information, it doesn’t include some critical detox genes, such as:
CYP2D6 – Plays a major role in drug metabolism.
SOD2 – A key antioxidant enzyme for cellular detoxification.
HMOX1 – Important for oxidative stress management.
Comprehensive Genetic Testing Options
If you're looking for a more detailed genetic analysis beyond what 23andMe offers, consider a more comprehensive DNA testing service. These options provide deeper insights into detox pathways, methylation, and overall health risks:
10X Health – Offers a genetic testing kit focused on methylation, detoxification, and personalized wellness.
Color Genomics – Provides personalized genetic health reports, including pharmacogenomics and hereditary risk assessments.
Invitae – Specializes in clinical-grade genetic testing, offering insights into hereditary disease risks and carrier screening.
These testing kits offer a broader range of health-related insights compared to 23andMe and may be helpful for those seeking more comprehensive detox and wellness genetic evaluations.
If you originally purchased only the Ancestry version of 23andMe, you may also have the option to upgrade to the Total Health report through your 23andMe account for additional insights.
Free vs. ChatGPT Pro (GPT-4 Turbo) for Genetic Analysis
Free ChatGPT: Can analyze genes but may have limited accuracy and struggle with complex SNP data.
ChatGPT Pro (GPT-4 Turbo): Much better at genetic interpretation, pattern recognition, and suggesting detox strategies.
For best results, ChatGPT Pro is recommended when analyzing raw genetic data.
Understanding & Supporting Your Detox Pathways
Using 23andMe ChatGPT to analyze your detox & mold-related genes is a powerful way to understand your body’s unique needs without expensive third-party tools. While genes aren’t destiny, they can provide valuable clues for optimizing detox pathways, reducing mold sensitivity, and personalizing your wellness plan.